http://www.mirror.co.uk/news/world-news/wikileaks-releases-thousands-turkish-ruling-8452235#rlabs=4%20rt$category%20p$8

http://www.mirror.co.uk/news/uk-news/revealed-full-horror-brutal-animal-8452471

Revealed: Full horror of brutal animal testing at government military lab sparks campaigners’ fury
22:41, 19 JUL 2016 UPDATED 22:41, 19 JUL 2016
BY MARTIN BAGOT
Cruel experiments include pigs being shot, rabbits blown up, guinea pigs paralysed with toxic nerve agent and monkeys given smallpox
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Getty Horror of secret military testing baseTests on pigs saw the animals shot and having their spleens removed
Horrific tests on animals involving the mutilation of pigs, rabbits and monkeys have been uncovered at a controversial government laboratory.

The “butchering” of these creatures which are shot, crushed, poisoned with toxic gas and infected with diseases, must be halted, say campaigners.

But officials claim there is no alternative to the tests if scientists are to learn how to properly protect the UK against terrorists and safeguard troops on the battlefield.

Freedom of Information figures show 7,373 experiments have been carried out since 2014 at secret Porton Down labs in Wiltshire. These included 124 on primates, 158 on pigs and 439 on guinea pigs.

In one Public Health England procedure, 21 highly intelligent long-tailed macaques were forced to inhale a version of the smallpox virus and observed for 12 days before being killed and dissected. Another test meant four rhesus macaques being infected with TB before being observed for two weeks. Two became so violently ill they had to be killed after one week.

A warning sign outside Porton Down
In other experiments, carried out by the MoD, pigs were shot, rabbits blown up and guinea pigs injected with a toxic nerve agent invented by the Nazis .

The Porton Down facility was opened 100 years ago in response to German gas attacks on British troops during the First World War.

During the 50s Cold War, scientists there developed CS or tear gas, used for crowd control in some countries. The unit is also home to a Category 4 laboratory which allows for the handling and storage of hazardous viruses such as Ebola . The number of animal tests have fallen, from 4,124 in 2014 to 3,249 in 2015.

READ MORE
Super-rats are being genetically modified to sniff out land mines for the army
But still many die as a result of the tests. And almost all that survive are put down.

Porton Down has a chequered history after using humans to test nerve gas there between 1939 and 1989.

Some volunteers who were ex-armed forces claim they were duped in to taking part in tests which ruined their health.

GettyHorror of secret military testing baseThe facility has carried out 7,373 animal tests in the last two years
But, to some animal rights campaigners, tests carried out today are just as controversial. The smallpox test on macaques was aimed at developing ways of combatting the virus if used as a biological weapon by terrorists.

After four days some of the monkeys began to cough and after six days they experienced severe weight loss, breathing difficulty, anorexia and increased body temperature.

They also developed hundreds of skin sores. In the test on the rhesus macaques, two had to be killed after 10 weeks after falling severely ill. All suffered weight loss, lung damage and pneumonia and were killed after 20 weeks.

In another horrific experiment, 24 large white pigs had their spleens removed before being shot four times with a bolt pistol to create severe muscle injuries in a rear thigh.

Scientists assessed the effects of extreme trauma and shock on the animals.

GettyHorror of secret military testing base124 primates have been used for tests including smallpox and TB
Blood was drained from them while they underwent “aggressive resuscitation techniques” before finally being killed.

And 38 rabbits were shot with compressed air to simulate severe blast injuries. Each were given 10 wounds between the knee and ankle while being kept alive for 12 hours.

Both pigs and rabbits in these tests were “terminally anaesthetised”.

In another test, guinea pigs were pumped with the toxic nerve agent Soman which was developed by the Nazis and used in the 1988 Iraq-Iran war. The gas is a weapon of mass destruction and is even more lethal than sarin.

Some guinea pigs suffered respiratory failure within 30 minutes of being injected, others struggled to breathe and became paralysed. Two thirds of the animals died within the 24-hour test period and those that survived had their necks broken.

Dr Katy TaylorDR KATY TAYLORDr Katy Taylor says the level of suffering is unacceptable
Dr Katy Taylor, director of science at Cruelty Free International, who uncovered the figures, said: “We all want to ensure the safety of soldiers and civilians.

“But we do not believe that animals need to be butchered or poisoned, or subjected to such cruel and disturbing experiments in order to achieve this.

“The level of suffering animals endure in military experiments conducted at Porton Down is completely unacceptable.

“There used to be additional parliamentary oversight of the experiments conducted at Porton Down, but shockingly this has been disbanded.

“Some of these controversial experiments appear only to be demonstrating the usefulness of techniques that are already being used on the battlefield.”

Colonel Hamish De Bretton GordonHamish De Bretton Gordon says tests are necessary
But Hamish de Bretton Gordon, former head of the British Army and NATO’s chemical weapons unit, said: “It is a necessary evil. ISIL, in particular, are trying ever more horrific methods to kill all those who oppose them – ie everybody in the UK – including the spectre of chemical and dirty bomb attack.

“Thousands of lives of British soldiers and civilians have been saved. Sometimes this has involved and must involve testing on animals, when no other lifesaving test is available.

Under UK law it is illegal to use animals in tests if there is an alternative way of finding the results.

Public Health England said: “The public want and expect vaccines that save lives and prevent serious infectious diseases and developing these is a top priority.

“Research only involves animals within the stringent guidelines laid down by Home Office regulations.”

For: Research has been a life-saver for our troops
Tom Holder, director of Speaking Of Research

Animal studies at Porton Down have a history of protecting the lives of those who protect us.

Research using pigs has shown that providing blood transfusions at the scene of an emergency improves the body’s ability to form clots and greatly increases the survival chances of those injured.

This technique is already saving lives in civilian emergencies as well as in combat zones.

At a time when the UK threat level from international terrorism is severe it would be irresponsible not to be doing everything possible to protect both military and civilian lives.

Porton Down research has allowed us to understand and protect against some of the most deadly weapons including sarin, VX and anthrax.

Thanks to strict UK regulations, such studies can only be conducted on animals when there is no other method available.

Many studies conducted at Porton Down are carried out under “terminal anaesthetic” – meaning that the animal is unconscious for the entire duration of the study and is never woken up but, instead, painlessly euthanised.

Against: Old-fashioned science is thin on justification
Dy Lindsay Marshall, Humane Society International

This is a shocking insight into highly secretive work. These are severe experiments in which animals will have suffered intense and prolonged pain and distress for little gain in terms of outcomes for human health.

There is little scientific justification. These experiments are based on old-fashioned science centred on the dubious premise that animals are a credible substitute for people.

It would be far better to utilise 21st century lab tools such as the “organ-on-a-chip” or synthetic cadavers.

For both smallpox and TB it seems the animal studies are duplicating what is already known; simply infecting animals and observing untreated disease progression until death is not adding to the body of data regarding effective therapies or vaccines for these diseases.

When it comes to traumatic injury, while pigs may be of a similar size to people, the animal response to pain and injury is notably different to humans and these large models are incredibly severe, distressing and upsetting. They are unlikely to gain acceptance by the public- especially if they knew alternatives are available.

http://www.mirror.co.uk/news/world-news/american-security-company-killed-dozens-8278176

http://www.mirror.co.uk/tech/scientists-create-human-chip-using-8364231

Scientists create ‘human on a chip’ using miniature organs as a cutting-edge way to test latest drugs
16:09, 7 JUL 2016 UPDATED 16:09, 7 JUL 2016
BY THEODORE WILSON
Modern science could change the way pharmaceuticals companies develop new medicines and potentially end animal testing
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COMMENTS

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Robo-sapiens? MIT’s 7 organ, human-on-a-chipRobo-sapiens? MIT’s 7 organ, human-on-a-chip
A team of British and US scientists have grown seven miniature human organs and combined them to create the world’s first ‘human-on-a-chip’.

Scientists from Oxfordshire-based CN Bio Innovations are presenting this $26 million dollar ‘man’ to the public today at the organ-on-a-chip World Congress 2016 being held in Boston, Massachussetts.

The tiny re-creation of a human uses real organ tissue to mimic the physiology of an actual person.

The purpose of this weird Robocop-like, ‘part human, part machine’ creation is really to aid scientist’s quest for safer and more effective medicines.

READ MORE
Fish eyes used to repair humans’ vision in answer to shortage of donor corneas
There’s no danger of it getting up and walking out of the lab though – it doesn’t have legs. Or, in fact, a brain that could operate them.

Organs on a chip could revolutionise drug testing
The end of animal testing
The strange, semi-organic mini-me doesn’t look like a human – and it isn’t supposed to. It’s primary function is a base on which to test new pharmaceuticals.

Instead it looks more like a big circuit board. Only instead of using copper tracks to carry electricity, it uses narrow channels to move a blood mimicking liquid around.

CLICK TO PLAY
Play
0:00
/
2:03
Fullscreen
Mute
Share
We shouldn’t hold this lack of resemblance to Homo sapiens against the revolutionary little piece of kit, because it is going to change the way pharmaceuticals companies develop new medicines and test existing ones.

Imagine rather than observing the effects of a new chemical on a lab rat, you could test a drug on an accurate, re-creation of a human in the lab.

“Pharmaceutical companies don’t love animal testing” said UK company CN Bio’s CEO, Dr Emma Sceats who is in Boston for the congress.

In fact, because of the limitations of animal testing, they are already using single organs-on-a-chip and other human cell technology to test the effects of new treatments.

Companies see artificial organs as an end to animal testing
The human-on-a-chip project was inspired by Dr Barry Pallotta, Program Manager at DARPA (The Defense Advanced Research Projects Agency, part of the US Department of Defense).

Speaking in 2015, Pallotta said he wanted to find “nascent technologies that can improve the drug and vaccine pipeline.” He explained “I knew the pipeline was failing, and I wanted to do something about it.”

READ MORE
Revolutionary ‘programmable’ vaccine could be key to stopping infectious diseases like Ebola, Zika and H1N1
His vision was for a box that contained human cells that would respond to vaccine or drug candidates in exactly the same way a human would.

DARPA ended up funding a couple of chip-based projects. This one is based on technology pioneered by MIT professor Linda Griffith, and is the result of collaboration between Griffith’s research group and CN Bio Innovations.

Re-creating a human in the lab
The channels and tiny ponds embedded in the ‘microfluidic’ human-on-a-chip device host real, functioning, organ tissue.

This tissue can be grown from stem cells or from human tissue collected during surgical procedures.

READ MORE
What exactly are stem cells? How the controversial issue is changing the world of medicine
The ‘organs’ are grown on three-dimensional scaffolds that allow the tissues to adopt natural structures.

Dr Sceats explains that “cells don’t like living in petri dishes”, and much prefer to be surrounded by other cells rather than hard plastic.

In the human body, organs are supplied with oxygen and food via circulating blood. The organs are connected by channels through which an oxygenated, nutrient rich liquid is pumped.

GettyHuman embryos on a petri dishHuman embryos on a petri dish
Keeping it all alive was a big challenge: “It has to be able to survive three weeks while we do the drug tests” said Dr Sceats.

Final form
In its final form, the human-on-a-chip will have 10 organs – liver, gut, heart, kidney, brain, lung, reproductive system, immune system, vascular system and skin.

Researchers will be able to monitor the effects of drugs on the bench top human, and look to see is a drug is toxic or beneficial for different organs or the system as a whole.

CN Bio specialise in making microfluidic livers, and Dr Sceats hopes that the technology will allow improve treatments for liver diseases whose treatment currently requires patient’s to have liver transplant.

READ MORE
Personalised drug treatment now possible thanks to pioneering stem cell research developed on Dolly, claim scientists
She wants the technique to test treatments that would allow organs to repair themselves in situ, that might use either a drug or some kind of stem cells.

CN Bio Innovations LiverChip could help produce treatments for hereditary liver diseases.CN Bio Innovations LiverChip could help produce treatments for hereditary liver diseases.
She also thinks that a human-on-a-chip will allow the testing of incredibly powerful, but potentially risky genetic treatments that will use “molecular scissors” to change a patients genome in situ .

Such therapies would allow doctors to treat hereditary genetic disorders.

Speaking about the risks such treatments could pose to patients, Dr Sceats said: “You’d better be damn sure you get it right”.

“[An] organ on a chip would be ideal for that kind of testing,” she said.

http://www.mirror.co.uk/news/world-news/american-security-company-killed-dozens-8278176

American security company ‘killed dozens of bomb sniffer dogs’ after contract ended
15:33, 25 JUN 2016 UPDATED 15:44, 25 JUN 2016
BY CHRISTOPHER BUCKTIN
WARNING: Contains distressing images. Animal rights activists allege Eastern Securities of Kuwait killed the Alsatians when they were no longer needed.
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RexAn AlsatianAn Alsatian
An American security company has been accused of killing dozens of bomb sniffing dog after its contract with a Middle Eastern old company ended.

Animal rights activists allege Eastern Securities of Kuwait of killing the Alsatians after they were no longer needed when its deal with Kuwait National Petroleum Company (KNPC ) allegedly ran out.

Pictures of their dead bodies were posted on Facebook showing them lying dead outside the cages they once occupied.

In one image a man is seen posing with his foot on one dead dog as three others lie in the foreground.
Campaigner Esmail Al Misri told the Arab Times that 90 more dogs could have been killed.

He alleged the animals were slaughtered as workers had not been paid by KNPC for two months.
“We know how dogs that are well-fed and well taken care of look. The photos were taken immediately after the incident so we can rule out dehydration as a cause of their sickly state,” said Al Misri, who has lodged a criminal complaint.

A worker for the Eastern Securities company told the Arab Times the firm was meant to humanely euthanise the dogs in small groups, but another employee “jumped the gun” and killed them all in one go.

Dozens of bomb sniffing dogs killed
He added the dogs were put down because they were ill or old, saying some had tumours, cataracts and problems with their hip joints.

It is not clear how the dogs were killed.

KNPC that said it was not involved with the killings.

In a statement it said the dogs had recently failed on a test of their ability to sniff out explosives.

The Mirror has contacted American-owned Eastern Securities of Kuwait for comment.

In addition to offices in Kuwait, Jordan and Iraq, Eastern Securities parent company Eastern Solutions Group has an office in Louisiana.
Dozens of bomb sniffing dogs killed

Comments (3)LOGIN
Sort

24 days ago
dynofon
These people must be the Rats of the Year. So typical of gun toting yanks these days.
ReplyShare00
24 days ago
ZakMichaelson
Another case of money over humanity. Hop you’re proud of yourselves america.
ReplyShare

http://www.mirror.co.uk/news/weird-news/super-rats-being-genetically-modified-8373497

Super-rats are being genetically modified to sniff out land mines for the army
21:20, 7 JUL 2016 UPDATED 21:21, 7 JUL 2016
BY JON VON-RADOWITZ
American scientists have already managed to create mice that can be programmed to detect specific smells
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GettyRatSuper-sniffer rats are being created by scientists
Rats with super-sensitive noses that can sniff out land mines are being developed in the US by military-funded researchers.

The project was approved after scientists created genetically modified “super-sniffer” mice that can be programmed to detect specific smells.

In laboratory experiments, the mice were given DNA that heightened their sensitivity to a sweet-smelling chemical and tiny traces of an unpleasant odour they tried to avoid.

Now the team from New York City University has received funding from the US Department of Defence to develop rats with the same ability that can detect explosives and potentially uncover land mines.

Other possible spin-offs from the research include a “nose-on-a-chip” that can diagnose diseases from their smell.

READ MORE
Dolly the sheep may have pushed stem cell research forward 20 years, says expert
The scientists, led by biologist Dr Paul Feinstein, wrote in the journal Cell Reports: “We have produced biosensors with an enhanced inherent sense of smell, which can be applied to address global health and safety challenges such as identification of explosives, contraband searches, and odour-based disease diagnosis.”

Land Mine RemovalThe genetically modified rodents could uncover land mines
Mammal noses contain a large collection of sensory neurons, each equipped with a single chemical sensor or “receptor” that detects a specific smell.

Collectively, the neurons have an even distribution of receptors sensitive to a broad range of odours.

The experimental mice have extra copies of a particular selected receptor, making them especially sensitive to a single smell.

In one behavioural test, animals with heightened sensitivity to an unpleasant odour were observed avoiding the smell in water.

READ MORE
These four genes determine if you have a nose like Cyrano de Bergerac or Kate Middleton, scientists reveal
They were able to detect far fainter traces of the odour than mice without super-sniffer abilities.

“The animals could smell the odour better because of the increased presence of the receptor,” said co-author Dr Charlotte D’Hulst, also from New York City University.

The researchers said they had founded a company called MouSensor to commercialise the genetic engineering technology.

Their laboratory had also received funding from the Department of Defence “to develop super-sniffing rats that can be trained to detect TNT and potentially find land mines”.

 

http://www.mirror.co.uk/news/world-news/wikileaks-releases-thousands-turkish-ruling-8452235#rlabs=4%20rt$category%20p$8

http://www.mirror.co.uk/news/uk-news/revealed-full-horror-brutal-animal-8452471

Revealed: Full horror of brutal animal testing at government military lab sparks campaigners’ fury
22:41, 19 JUL 2016 UPDATED 22:41, 19 JUL 2016
BY MARTIN BAGOT
Cruel experiments include pigs being shot, rabbits blown up, guinea pigs paralysed with toxic nerve agent and monkeys given smallpox
SHARES

COMMENTS

Enter your e-mail for our politics newsletter

Getty Horror of secret military testing baseTests on pigs saw the animals shot and having their spleens removed
Horrific tests on animals involving the mutilation of pigs, rabbits and monkeys have been uncovered at a controversial government laboratory.

The “butchering” of these creatures which are shot, crushed, poisoned with toxic gas and infected with diseases, must be halted, say campaigners.

But officials claim there is no alternative to the tests if scientists are to learn how to properly protect the UK against terrorists and safeguard troops on the battlefield.

Freedom of Information figures show 7,373 experiments have been carried out since 2014 at secret Porton Down labs in Wiltshire. These included 124 on primates, 158 on pigs and 439 on guinea pigs.

In one Public Health England procedure, 21 highly intelligent long-tailed macaques were forced to inhale a version of the smallpox virus and observed for 12 days before being killed and dissected. Another test meant four rhesus macaques being infected with TB before being observed for two weeks. Two became so violently ill they had to be killed after one week.

A warning sign outside Porton Down
In other experiments, carried out by the MoD, pigs were shot, rabbits blown up and guinea pigs injected with a toxic nerve agent invented by the Nazis .

The Porton Down facility was opened 100 years ago in response to German gas attacks on British troops during the First World War.

During the 50s Cold War, scientists there developed CS or tear gas, used for crowd control in some countries. The unit is also home to a Category 4 laboratory which allows for the handling and storage of hazardous viruses such as Ebola . The number of animal tests have fallen, from 4,124 in 2014 to 3,249 in 2015.

READ MORE
Super-rats are being genetically modified to sniff out land mines for the army
But still many die as a result of the tests. And almost all that survive are put down.

Porton Down has a chequered history after using humans to test nerve gas there between 1939 and 1989.

Some volunteers who were ex-armed forces claim they were duped in to taking part in tests which ruined their health.

GettyHorror of secret military testing baseThe facility has carried out 7,373 animal tests in the last two years
But, to some animal rights campaigners, tests carried out today are just as controversial. The smallpox test on macaques was aimed at developing ways of combatting the virus if used as a biological weapon by terrorists.

After four days some of the monkeys began to cough and after six days they experienced severe weight loss, breathing difficulty, anorexia and increased body temperature.

They also developed hundreds of skin sores. In the test on the rhesus macaques, two had to be killed after 10 weeks after falling severely ill. All suffered weight loss, lung damage and pneumonia and were killed after 20 weeks.

In another horrific experiment, 24 large white pigs had their spleens removed before being shot four times with a bolt pistol to create severe muscle injuries in a rear thigh.

Scientists assessed the effects of extreme trauma and shock on the animals.

GettyHorror of secret military testing base124 primates have been used for tests including smallpox and TB
Blood was drained from them while they underwent “aggressive resuscitation techniques” before finally being killed.

And 38 rabbits were shot with compressed air to simulate severe blast injuries. Each were given 10 wounds between the knee and ankle while being kept alive for 12 hours.

Both pigs and rabbits in these tests were “terminally anaesthetised”.

In another test, guinea pigs were pumped with the toxic nerve agent Soman which was developed by the Nazis and used in the 1988 Iraq-Iran war. The gas is a weapon of mass destruction and is even more lethal than sarin.

Some guinea pigs suffered respiratory failure within 30 minutes of being injected, others struggled to breathe and became paralysed. Two thirds of the animals died within the 24-hour test period and those that survived had their necks broken.

Dr Katy TaylorDR KATY TAYLORDr Katy Taylor says the level of suffering is unacceptable
Dr Katy Taylor, director of science at Cruelty Free International, who uncovered the figures, said: “We all want to ensure the safety of soldiers and civilians.

“But we do not believe that animals need to be butchered or poisoned, or subjected to such cruel and disturbing experiments in order to achieve this.

“The level of suffering animals endure in military experiments conducted at Porton Down is completely unacceptable.

“There used to be additional parliamentary oversight of the experiments conducted at Porton Down, but shockingly this has been disbanded.

“Some of these controversial experiments appear only to be demonstrating the usefulness of techniques that are already being used on the battlefield.”

Colonel Hamish De Bretton GordonHamish De Bretton Gordon says tests are necessary
But Hamish de Bretton Gordon, former head of the British Army and NATO’s chemical weapons unit, said: “It is a necessary evil. ISIL, in particular, are trying ever more horrific methods to kill all those who oppose them – ie everybody in the UK – including the spectre of chemical and dirty bomb attack.

“Thousands of lives of British soldiers and civilians have been saved. Sometimes this has involved and must involve testing on animals, when no other lifesaving test is available.

Under UK law it is illegal to use animals in tests if there is an alternative way of finding the results.

Public Health England said: “The public want and expect vaccines that save lives and prevent serious infectious diseases and developing these is a top priority.

“Research only involves animals within the stringent guidelines laid down by Home Office regulations.”

For: Research has been a life-saver for our troops
Tom Holder, director of Speaking Of Research

Animal studies at Porton Down have a history of protecting the lives of those who protect us.

Research using pigs has shown that providing blood transfusions at the scene of an emergency improves the body’s ability to form clots and greatly increases the survival chances of those injured.

This technique is already saving lives in civilian emergencies as well as in combat zones.

At a time when the UK threat level from international terrorism is severe it would be irresponsible not to be doing everything possible to protect both military and civilian lives.

Porton Down research has allowed us to understand and protect against some of the most deadly weapons including sarin, VX and anthrax.

Thanks to strict UK regulations, such studies can only be conducted on animals when there is no other method available.

Many studies conducted at Porton Down are carried out under “terminal anaesthetic” – meaning that the animal is unconscious for the entire duration of the study and is never woken up but, instead, painlessly euthanised.

Against: Old-fashioned science is thin on justification
Dy Lindsay Marshall, Humane Society International

This is a shocking insight into highly secretive work. These are severe experiments in which animals will have suffered intense and prolonged pain and distress for little gain in terms of outcomes for human health.

There is little scientific justification. These experiments are based on old-fashioned science centred on the dubious premise that animals are a credible substitute for people.

It would be far better to utilise 21st century lab tools such as the “organ-on-a-chip” or synthetic cadavers.

For both smallpox and TB it seems the animal studies are duplicating what is already known; simply infecting animals and observing untreated disease progression until death is not adding to the body of data regarding effective therapies or vaccines for these diseases.

When it comes to traumatic injury, while pigs may be of a similar size to people, the animal response to pain and injury is notably different to humans and these large models are incredibly severe, distressing and upsetting. They are unlikely to gain acceptance by the public- especially if they knew alternatives are available.

http://www.mirror.co.uk/news/world-news/american-security-company-killed-dozens-8278176

http://www.mirror.co.uk/tech/scientists-create-human-chip-using-8364231

Scientists create ‘human on a chip’ using miniature organs as a cutting-edge way to test latest drugs
16:09, 7 JUL 2016 UPDATED 16:09, 7 JUL 2016
BY THEODORE WILSON
Modern science could change the way pharmaceuticals companies develop new medicines and potentially end animal testing
SHARES

COMMENTS

Enter your e-mail for our daily newsletter

Robo-sapiens? MIT’s 7 organ, human-on-a-chipRobo-sapiens? MIT’s 7 organ, human-on-a-chip
A team of British and US scientists have grown seven miniature human organs and combined them to create the world’s first ‘human-on-a-chip’.

Scientists from Oxfordshire-based CN Bio Innovations are presenting this $26 million dollar ‘man’ to the public today at the organ-on-a-chip World Congress 2016 being held in Boston, Massachussetts.

The tiny re-creation of a human uses real organ tissue to mimic the physiology of an actual person.

The purpose of this weird Robocop-like, ‘part human, part machine’ creation is really to aid scientist’s quest for safer and more effective medicines.

READ MORE
Fish eyes used to repair humans’ vision in answer to shortage of donor corneas
There’s no danger of it getting up and walking out of the lab though – it doesn’t have legs. Or, in fact, a brain that could operate them.

Organs on a chip could revolutionise drug testing
The end of animal testing
The strange, semi-organic mini-me doesn’t look like a human – and it isn’t supposed to. It’s primary function is a base on which to test new pharmaceuticals.

Instead it looks more like a big circuit board. Only instead of using copper tracks to carry electricity, it uses narrow channels to move a blood mimicking liquid around.

CLICK TO PLAY
Play
0:00
/
2:03
Fullscreen
Mute
Share
We shouldn’t hold this lack of resemblance to Homo sapiens against the revolutionary little piece of kit, because it is going to change the way pharmaceuticals companies develop new medicines and test existing ones.

Imagine rather than observing the effects of a new chemical on a lab rat, you could test a drug on an accurate, re-creation of a human in the lab.

“Pharmaceutical companies don’t love animal testing” said UK company CN Bio’s CEO, Dr Emma Sceats who is in Boston for the congress.

In fact, because of the limitations of animal testing, they are already using single organs-on-a-chip and other human cell technology to test the effects of new treatments.

Companies see artificial organs as an end to animal testing
The human-on-a-chip project was inspired by Dr Barry Pallotta, Program Manager at DARPA (The Defense Advanced Research Projects Agency, part of the US Department of Defense).

Speaking in 2015, Pallotta said he wanted to find “nascent technologies that can improve the drug and vaccine pipeline.” He explained “I knew the pipeline was failing, and I wanted to do something about it.”

READ MORE
Revolutionary ‘programmable’ vaccine could be key to stopping infectious diseases like Ebola, Zika and H1N1
His vision was for a box that contained human cells that would respond to vaccine or drug candidates in exactly the same way a human would.

DARPA ended up funding a couple of chip-based projects. This one is based on technology pioneered by MIT professor Linda Griffith, and is the result of collaboration between Griffith’s research group and CN Bio Innovations.

Re-creating a human in the lab
The channels and tiny ponds embedded in the ‘microfluidic’ human-on-a-chip device host real, functioning, organ tissue.

This tissue can be grown from stem cells or from human tissue collected during surgical procedures.

READ MORE
What exactly are stem cells? How the controversial issue is changing the world of medicine
The ‘organs’ are grown on three-dimensional scaffolds that allow the tissues to adopt natural structures.

Dr Sceats explains that “cells don’t like living in petri dishes”, and much prefer to be surrounded by other cells rather than hard plastic.

In the human body, organs are supplied with oxygen and food via circulating blood. The organs are connected by channels through which an oxygenated, nutrient rich liquid is pumped.

GettyHuman embryos on a petri dishHuman embryos on a petri dish
Keeping it all alive was a big challenge: “It has to be able to survive three weeks while we do the drug tests” said Dr Sceats.

Final form
In its final form, the human-on-a-chip will have 10 organs – liver, gut, heart, kidney, brain, lung, reproductive system, immune system, vascular system and skin.

Researchers will be able to monitor the effects of drugs on the bench top human, and look to see is a drug is toxic or beneficial for different organs or the system as a whole.

CN Bio specialise in making microfluidic livers, and Dr Sceats hopes that the technology will allow improve treatments for liver diseases whose treatment currently requires patient’s to have liver transplant.

READ MORE
Personalised drug treatment now possible thanks to pioneering stem cell research developed on Dolly, claim scientists
She wants the technique to test treatments that would allow organs to repair themselves in situ, that might use either a drug or some kind of stem cells.

CN Bio Innovations LiverChip could help produce treatments for hereditary liver diseases.CN Bio Innovations LiverChip could help produce treatments for hereditary liver diseases.
She also thinks that a human-on-a-chip will allow the testing of incredibly powerful, but potentially risky genetic treatments that will use “molecular scissors” to change a patients genome in situ .

Such therapies would allow doctors to treat hereditary genetic disorders.

Speaking about the risks such treatments could pose to patients, Dr Sceats said: “You’d better be damn sure you get it right”.

“[An] organ on a chip would be ideal for that kind of testing,” she said.

http://www.mirror.co.uk/news/world-news/american-security-company-killed-dozens-8278176

American security company ‘killed dozens of bomb sniffer dogs’ after contract ended
15:33, 25 JUN 2016 UPDATED 15:44, 25 JUN 2016
BY CHRISTOPHER BUCKTIN
WARNING: Contains distressing images. Animal rights activists allege Eastern Securities of Kuwait killed the Alsatians when they were no longer needed.
SHARES

3
COMMENTS

Enter your e-mail for our daily newsletter

RexAn AlsatianAn Alsatian
An American security company has been accused of killing dozens of bomb sniffing dog after its contract with a Middle Eastern old company ended.

Animal rights activists allege Eastern Securities of Kuwait of killing the Alsatians after they were no longer needed when its deal with Kuwait National Petroleum Company (KNPC ) allegedly ran out.

Pictures of their dead bodies were posted on Facebook showing them lying dead outside the cages they once occupied.

In one image a man is seen posing with his foot on one dead dog as three others lie in the foreground.
Campaigner Esmail Al Misri told the Arab Times that 90 more dogs could have been killed.

He alleged the animals were slaughtered as workers had not been paid by KNPC for two months.
“We know how dogs that are well-fed and well taken care of look. The photos were taken immediately after the incident so we can rule out dehydration as a cause of their sickly state,” said Al Misri, who has lodged a criminal complaint.

A worker for the Eastern Securities company told the Arab Times the firm was meant to humanely euthanise the dogs in small groups, but another employee “jumped the gun” and killed them all in one go.

Dozens of bomb sniffing dogs killed
He added the dogs were put down because they were ill or old, saying some had tumours, cataracts and problems with their hip joints.

It is not clear how the dogs were killed.

KNPC that said it was not involved with the killings.

In a statement it said the dogs had recently failed on a test of their ability to sniff out explosives.

The Mirror has contacted American-owned Eastern Securities of Kuwait for comment.

In addition to offices in Kuwait, Jordan and Iraq, Eastern Securities parent company Eastern Solutions Group has an office in Louisiana.
Dozens of bomb sniffing dogs killed

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24 days ago
dynofon
These people must be the Rats of the Year. So typical of gun toting yanks these days.
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24 days ago
ZakMichaelson
Another case of money over humanity. Hop you’re proud of yourselves america.
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http://www.mirror.co.uk/news/weird-news/super-rats-being-genetically-modified-8373497

Super-rats are being genetically modified to sniff out land mines for the army
21:20, 7 JUL 2016 UPDATED 21:21, 7 JUL 2016
BY JON VON-RADOWITZ
American scientists have already managed to create mice that can be programmed to detect specific smells
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GettyRatSuper-sniffer rats are being created by scientists
Rats with super-sensitive noses that can sniff out land mines are being developed in the US by military-funded researchers.

The project was approved after scientists created genetically modified “super-sniffer” mice that can be programmed to detect specific smells.

In laboratory experiments, the mice were given DNA that heightened their sensitivity to a sweet-smelling chemical and tiny traces of an unpleasant odour they tried to avoid.

Now the team from New York City University has received funding from the US Department of Defence to develop rats with the same ability that can detect explosives and potentially uncover land mines.

Other possible spin-offs from the research include a “nose-on-a-chip” that can diagnose diseases from their smell.

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The scientists, led by biologist Dr Paul Feinstein, wrote in the journal Cell Reports: “We have produced biosensors with an enhanced inherent sense of smell, which can be applied to address global health and safety challenges such as identification of explosives, contraband searches, and odour-based disease diagnosis.”

Land Mine RemovalThe genetically modified rodents could uncover land mines
Mammal noses contain a large collection of sensory neurons, each equipped with a single chemical sensor or “receptor” that detects a specific smell.

Collectively, the neurons have an even distribution of receptors sensitive to a broad range of odours.

The experimental mice have extra copies of a particular selected receptor, making them especially sensitive to a single smell.

In one behavioural test, animals with heightened sensitivity to an unpleasant odour were observed avoiding the smell in water.

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These four genes determine if you have a nose like Cyrano de Bergerac or Kate Middleton, scientists reveal
They were able to detect far fainter traces of the odour than mice without super-sniffer abilities.

“The animals could smell the odour better because of the increased presence of the receptor,” said co-author Dr Charlotte D’Hulst, also from New York City University.

The researchers said they had founded a company called MouSensor to commercialise the genetic engineering technology.

Their laboratory had also received funding from the Department of Defence “to develop super-sniffing rats that can be trained to detect TNT and potentially find land mines”.

http://www.mirror.co.uk/news/world-news/wikileaks-releases-thousands-turkish-ruling-8452235#rlabs=4%20rt$category%20p$8

WikiLeaks releases thousands of Turkish ruling AKP Party’s private emails in response to government’s post coup purge
21:44, 19 JUL 2016 UPDATED 22:13, 19 JUL 2016
BY SAM ADAMS
It comes in response to the purge by the government of President Recep Tayyip Erdogan of the country’s political, military and educational classes following the apparent attempted coup last week
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GettyWikiLeaks founder Julian Assange WikiLeaks, founded by Julian Assange (pictured), has released thousands of emails
Wikileaks has released the first of thousands of private emails sent by senior members of Turkey’s AKP Party.

It comes in response to the purge by the government of President Recep Tayyip Erdogan of the country’s political, military and educational classes following the apparent attempted coup last week.

In a statement on its website, Wikileaks said: “Today, 11pm Anakara Time, WikiLeaks releases part one of the AKP Emails. AKP, or the Justice & Development Party, is the ruling party of Turkey and is the political force behind the country’s president, Recep Tayyip Erdoğan.

WikileaksWikileaks homepage after dropping emails from the AKP or the Justice & Development Party, the ruling party of TurkeyWikileaks homepage after dropping emails from the AKP or the Justice & Development Party, the ruling party of Turkey
“Part one of the series covers 762 mail boxes beginning with ‘A’ through to ‘I’ containing 294,548 email bodies together with many thousands of attached files. The emails come from “akparti.org.tr”, the AKP’s primary domain.

“The most recent was sent on July 6, 2016. The oldest dates back to 2010.

GettyTurkey’s President Recep Tayyip Erdogan
“It should be noted that emails associated with the domain are mostly used for dealing with the world, as opposed to the most sensitive internal matters.

“The material was obtained a week before the attempted coup. However, WikiLeaks has moved forward its publication schedule in response to the government’s post-coup purges. We have verified the material and the source, who is not connected, in any way, to the elements behind the attempted coup, or to a rival political party or state.”

Tensions remain high in Turkey as the government rounds up and arrested tens of thousands of military officers, teachers and other state workers and blocks news outlets in the fallout from Friday’s coup.

Turkey has banned Islamic funerals for dead coup supporters and warned imams not to carry out the ceremonies.

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Hundreds of people were killed in the apparent attempted coup last Friday which was crushed by the government of President Recep Tayyip Erdogan.

The Religious Affairs Directorate announced today that imams would not lead prayers for “pro-coup soldiers who targeted our nation”.

The state directly employees all of Turkey’s 75,000 imams.

Around 20 alleged coup supporters were killed during fighting. Around 240 other people also died in the violence, including 145 civilians.Turkey has banned Islamic funerals for dead coup supporters and warned imams not to carry out the ceremonies.

Hundreds of people were killed in the apparent attempted coup last Friday which was crushed by the government of President Recep Tayyip Erdogan.

The Religious Affairs Directorate announced today that imams would not lead prayers for “pro-coup soldiers who targeted our nation”.

The state directly employees all of Turkey’s 75,000 imams.

 

Around 20 alleged coup supporters were killed during fighting. Around 240 other people also died in the violence, including 145 civilians.

 

http://www.mirror.co.uk/news/world-news/turkey-bans-islamic-funerals-dead-8451940#rlabs=61%20rt$category%20p$3

 

http://www.mirror.co.uk/news/world-news/turkey-bans-islamic-funerals-dead-8451940#rlabs=61%20rt$category%20p$3

 

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